The cardiovascular risks of thiazide diuretics.
نویسنده
چکیده
It is not surprising that a discipline as rapidly growing and changing as the management of hypertension should engender a number of controversies. These disagreements may have considerable medical, economic, and public health impact simply because there are so many millions of patients with hypertension involved. The purpose of this discussion is to present what some would consider controversial points of view concerning the safety of thiazide diuretics.
منابع مشابه
Effects of thiazide-type and thiazide-like diuretics on cardiovascular events and mortality: systematic review and meta-analysis.
Thiazide diuretics are recommended as first-line therapy for hypertension and are among the most commonly prescribed drugs worldwide. According to their molecular structure, thiazide diuretics can be divided in thiazide-type (TT) and thiazide-like (TL) diuretics. TL diuretics have a longer elimination half-life compared with TT diuretics and have been shown to exert additional pharmacological e...
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Thiazide (hydrochlorothiazide,...) and thiazide-like (chlortalidone, indapamide,...) diuretics are widely used to treat hypertensive patients. There is growing evidence that these diuretics are not interchangeable and that it might be preferable to choose a thiazide-like diuretic whenever the use of a diuretic is considered. This is in order to prevent optimally the development of cardiovascula...
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UNLABELLED Thiazide diuretics are effective antihypertensive medications shown to reduce the risk of cardiovascular events and stroke. Despite being the preferred choice for uncomplicated essential hypertension, thiazide diuretics continue to be underutilized. METHODS Uncomplicated essential hypertension patients taking a single antihypertensive medication were evaluated upon enrollment, diag...
متن کاملUse of diuretics in cardiovascular disease: (2) hypertension.
Hypertension is a common condition associated with increased mortality and multiple morbidities. Evidence based management of hypertension is known to improve both the short term and the long term outcomes in patients with this condition. There are several general measures and pharmacological agents that are known to treat hypertension adequately. Diuretics, in particular low dose thiazide and ...
متن کاملTrends in first-line therapy for hypertension in the Cardiovascular Research Network Hypertension Registry, 2002-2007.
S ince publication of the Antihypertensive and LipidLowering Treatment to Prevent Heart Attack Trial (ALLHAT) (December 2002) and Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-7) (May 2003) guidelines, thiazide diuretics have been promoted as the preferred initial agents for hypertension treatment, especially among...
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ورودعنوان ژورنال:
- Clinical pharmacology and therapeutics
دوره 39 3 شماره
صفحات -
تاریخ انتشار 1986